London Stadium will play host to Saracensâ€™ Derby Day fixture against Harlequins on Saturday 24th March.
The game, which has become a highlight of the Saracens calendar, will see this seasonâ€™s London derby played in front of 57,000 fans at the Aviva Premiership fixture to be hosted at London Stadium.
Saracens will make the move to Queen Elizabeth Olympic Park, which hosted a number of matches during the 2015 World Cup, after a successful multi year partnership with Wembley Stadium which has seen the innovative north London club take 14 Premiership and European fixtures to the National Stadium and achieve a world record crowds throughout its tenure.
Saracens CEO Heath Harvey said: â€œAs a visionary and innovative club we are delighted to be teaming up with a stadium and team that matches our ambition to create a landmark showpiece event.
â€œLondon Stadium has become synonymous with delivering great entertainment and sporting spectacles and this opportunity is one that both parties are very excited about.
â€œWe have enjoyed a number of successful years with Wembley Stadium however despite continued attempts over the past year to build on the long term relationship Wembley have not matched our ambition.â€
London Stadium Chief Executive Linda Lennon CBE said: "We are delighted to announce our partnership with Saracens and look forward to welcoming their supporters for a fixture of such prestige.
"We take immense pride in delivering a diverse calendar of events and look forward to building a strong bond with Saracens and their supporters."
Full details of ticketing arrangements for the game will be announced soon.